The Basicity Makes the Difference: Improved Canavanine-Derived Inhibitors of the Proprotein Convertase Furin

[Image: see text] Furin activates numerous viral glycoproteins, and its inhibition prevents virus replication and spread. Through the replacement of arginine by the less basic canavanine, new inhibitors targeting furin in the trans-Golgi network were developed. These inhibitors exert potent antivira...

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Publicat a:ACS Med Chem Lett
Autors principals: Lam van, Thuy Van, Heindl, Miriam Ruth, Schlutt, Christine, Böttcher-Friebertshäuser, Eva, Bartenschlager, Ralf, Klebe, Gerhard, Brandstetter, Hans, Dahms, Sven O., Steinmetzer, Torsten
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2021
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7957917/
https://ncbi.nlm.nih.gov/pubmed/33732412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.0c00651
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