Design and Evaluation of Peptide Dual-Agonists of GLP-1 and NPY2 Receptors for Glucoregulation and Weight Loss with Mitigated Nausea and Emesis

[Image: see text] There is a critical unmet need for therapeutics to treat the epidemic of comorbidities associated with obesity and type 2 diabetes, ideally devoid of nausea/emesis. This study developed monomeric peptide agonists of glucagon-like peptide 1 receptor (GLP-1R) and neuropeptide Y2 rece...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Milliken, Brandon T., Elfers, Clinton, Chepurny, Oleg G., Chichura, Kylie S., Sweet, Ian R., Borner, Tito, Hayes, Matthew R., De Jonghe, Bart C., Holz, George G., Roth, Christian L., Doyle, Robert P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2021
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7956155/
https://ncbi.nlm.nih.gov/pubmed/33449689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.0c01783
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