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On selecting the critical boundary functions in group-sequential trials with two time-to-event outcomes

We investigate selection of critical boundary functions for testing the hypotheses of two time-to-event outcomes as both primary endpoints or a primary and a secondary endpoint in group-sequential clinical trials, where (1) the effect sizes of endpoints are unequal, or (2) one endpoint is for short-...

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Опубликовано в: :Contemp Clin Trials
Главные авторы: Hamasaki, Toshimitsu, Hung, H.M. James, Hsiao, Chin-Fu, Evans, Scott R.
Формат: Artigo
Язык:Inglês
Опубликовано: 2020
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7954908/
https://ncbi.nlm.nih.gov/pubmed/33309946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cct.2020.106244
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