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Sample size determination in group-sequential clinical trials with two co-primary endpoints

We discuss sample size determination in group-sequential designs with two endpoints as co-primary. We derive the power and sample size within two decision-making frameworks. One is to claim the test intervention’s benefit relative to control when superiority is achieved for the two endpoints at the...

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Main Authors: Asakura, Koko, Hamasaki, Toshimitsu, Sugimoto, Tomoyuki, Hayashi, Kenichi, Evans, Scott R, Sozu, Takashi
格式: Artigo
語言:Inglês
出版: 2014
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4082481/
https://ncbi.nlm.nih.gov/pubmed/24676799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sim.6154
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