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Sample size determination in group-sequential clinical trials with two co-primary endpoints
We discuss sample size determination in group-sequential designs with two endpoints as co-primary. We derive the power and sample size within two decision-making frameworks. One is to claim the test intervention’s benefit relative to control when superiority is achieved for the two endpoints at the...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2014
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4082481/ https://ncbi.nlm.nih.gov/pubmed/24676799 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sim.6154 |
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