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Interim evaluation of efficacy or futility in group-sequential trials with multiple co-primary endpoints

We discuss group-sequential designs in superiority clinical trials with multiple co-primary endpoints, i.e., when trials are designed to evaluate if the test intervention is superior to the control on all primary endpoints. We consider several decision-making frameworks for evaluating efficacy or fu...

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Foilsithe in:Biom J
Main Authors: Asakura, Koko, Hamasaki, Toshimitsu, Evans, Scott R.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2016
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6222168/
https://ncbi.nlm.nih.gov/pubmed/27757980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bimj.201600026
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