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Interim Monitoring for Futility in Clinical Trials with Two Co-primary Endpoints Using Prediction

We discuss using prediction as a flexible and practical approach for monitoring futility in clinical trials with two co-primary endpoints. This approach is appealing in that it provides quantitative evaluation of potential effect sizes and associated precision, and can be combined with flexible erro...

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Detalhes bibliográficos
Publicado no:Stat Biopharm Res
Main Authors: Asakura, Koko, Evans, Scott R., Hamasaki, Toshimitsu
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7539647/
https://ncbi.nlm.nih.gov/pubmed/33042476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19466315.2019.1677494
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