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A logrank test-based method for sizing clinical trials with two co-primary time-to-event endpoints
We discuss sample size determination for clinical trials evaluating the joint effects of an intervention on two potentially correlated co-primary time-to-event endpoints. For illustration, we consider the most common case, a comparison of two randomized groups, and use typical copula families to mod...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4148615/ https://ncbi.nlm.nih.gov/pubmed/23307913 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/biostatistics/kxs057 |
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