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Group-sequential logrank methods for trial designs using bivariate non-competing event-time outcomes

We discuss the multivariate (2L-variate) correlation structure and the asymptotic distribution for the group-sequential weighted logrank statistics formulated when monitoring two correlated event-time outcomes in clinical trials. The asymptotic distribution and the variance-covariance for the 2L-var...

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Pubblicato in:Lifetime Data Anal
Autori principali: Sugimoto, Tomoyuki, Hamasaki, Toshimitsu, Evans, Scott R., Halabi, Susan
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7517875/
https://ncbi.nlm.nih.gov/pubmed/30980317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10985-019-09470-4
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