USP13 regulates the replication stress response by deubiquitinating TopBP1

The DNA replication stress-induced checkpoint activated through the TopBP1-ATR axis is important for maintaining genomic stability. However, the regulation of TopBP1 in DNA-damage responses remains unclear. In this study, we identify the deubiquitinating enzyme (DUB) USP13 as an important regulator...

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Publicat a:DNA Repair (Amst)
Autors principals: Kim, Wootae, Zhao, Fei, Gao, Huanyao, Qin, Sisi, Hou, Jing, Deng, Min, Kloeber, Jake A, Huang, Jinzhou, Zhou, Qin, Guo, Guijie, Gao, Ming, Zeng, Xiangyu, Zhu, Shouhai, Tu, Xinyi, Wu, Zheming, Zhang, Yong, Yin, Ping, Kaufmann, Scott H, Luo, Kuntian, Lou, Zhenkun
Format: Artigo
Idioma:Inglês
Publicat: 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7951086/
https://ncbi.nlm.nih.gov/pubmed/33592542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2021.103063
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