LRRK2 inhibition potentiates PARP inhibitor cytotoxicity through inhibiting homologous recombination‐mediated DNA double strand break repair

PARP inhibitors induce DNA lesions, the repair of which are highly dependent on homologous recombination (HR), and preferentially kill HR‐ deficient cancers. However, cancer cells have developed several mechanisms to transform HR and confer drug resistance to PARP inhibition. Therefore, there is a g...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Clin Transl Med
Main Authors: Chen, Lifeng, Hou, Jing, Zeng, Xiangyu, Guo, Qiang, Deng, Min, Kloeber, Jake A, Tu, Xinyi, Zhao, Fei, Wu, Zheming, Huang, Jinzhou, Luo, Kuntian, Kim, Wootae, Lou, Zhenkun
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2021
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7908045/
https://ncbi.nlm.nih.gov/pubmed/33784003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ctm2.341
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados