LRRK2 inhibition potentiates PARP inhibitor cytotoxicity through inhibiting homologous recombination‐mediated DNA double strand break repair

PARP inhibitors induce DNA lesions, the repair of which are highly dependent on homologous recombination (HR), and preferentially kill HR‐ deficient cancers. However, cancer cells have developed several mechanisms to transform HR and confer drug resistance to PARP inhibition. Therefore, there is a g...

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Dades bibliogràfiques
Publicat a:Clin Transl Med
Autors principals: Chen, Lifeng, Hou, Jing, Zeng, Xiangyu, Guo, Qiang, Deng, Min, Kloeber, Jake A, Tu, Xinyi, Zhao, Fei, Wu, Zheming, Huang, Jinzhou, Luo, Kuntian, Kim, Wootae, Lou, Zhenkun
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2021
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7908045/
https://ncbi.nlm.nih.gov/pubmed/33784003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ctm2.341
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