The deubiquitinase USP36 Regulates DNA replication stress and confers therapeutic resistance through PrimPol stabilization

PrimPol has been recently identified as a DNA damage tolerant polymerase that plays an important role in replication stress response. However, the regulatory mechanisms of PrimPol are not well defined. In this study, we identify that the deubiquitinase USP36 interferes with degradation of PrimPol to...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Nucleic Acids Res
Egile Nagusiak: Yan, Yuanliang, Xu, Zhijie, Huang, Jinzhou, Guo, Guijie, Gao, Ming, Kim, Wootae, Zeng, Xiangyu, Kloeber, Jake A, Zhu, Qian, Zhao, Fei, Luo, Kuntian, Lou, Zhenkun
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Oxford University Press 2020
Gaiak:
Genome Integrity, Repair and Replication
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7736794/
https://ncbi.nlm.nih.gov/pubmed/33237263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa1090
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