The deubiquitinase USP36 Regulates DNA replication stress and confers therapeutic resistance through PrimPol stabilization

PrimPol has been recently identified as a DNA damage tolerant polymerase that plays an important role in replication stress response. However, the regulatory mechanisms of PrimPol are not well defined. In this study, we identify that the deubiquitinase USP36 interferes with degradation of PrimPol to...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Yan, Yuanliang, Xu, Zhijie, Huang, Jinzhou, Guo, Guijie, Gao, Ming, Kim, Wootae, Zeng, Xiangyu, Kloeber, Jake A, Zhu, Qian, Zhao, Fei, Luo, Kuntian, Lou, Zhenkun
Format: Artigo
Language:Inglês
Published: Oxford University Press 2020
Subjects:
Genome Integrity, Repair and Replication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7736794/
https://ncbi.nlm.nih.gov/pubmed/33237263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa1090
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