ABHD5 suppresses cancer cell anabolism through lipolysis-dependent activation of the AMPK/mTORC1 pathway

ABHD5 is an essential coactivator of ATGL, the rate-limiting triglyceride (TG) lipase in many cell types. Importantly, ABHD5 also functions as a tumor suppressor, and ABHD5 mRNA expression levels correlate with patient survival for several cancers. Nevertheless, the mechanisms involved in ABHD5-depe...

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Detaylı Bibliyografya
Yayımlandı:J Biol Chem
Asıl Yazarlar: Chen, Guohua, Zhou, Guoli, Lotvola, Aaron, Granneman, James G., Wang, Jian
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2020
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7949079/
https://ncbi.nlm.nih.gov/pubmed/33219129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.014682
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