OTUB1 protein suppresses mTOR complex 1 (mTORC1) activity by deubiquitinating the mTORC1 inhibitor DEPTOR

Mechanistic target of rapamycin (mTOR) complex 1 (mTORC1) integrates various environmental signals to regulate cell growth and metabolism. DEPTOR, also termed DEPDC6, is an endogenous inhibitor of mTORC1 and mTORC2 activities. The abundance of DEPTOR centrally orchestrates the mTOR signaling network...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Zhao, Linlin, Wang, Xinbo, Yu, Yue, Deng, Lu, Chen, Lei, Peng, Xiaoping, Jiao, Chenchen, Gao, Guoli, Tan, Xiao, Pan, Weijuan, Ge, Xin, Wang, Ping
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5880136/
https://ncbi.nlm.nih.gov/pubmed/29382726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.809533
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