OTUB1 protein suppresses mTOR complex 1 (mTORC1) activity by deubiquitinating the mTORC1 inhibitor DEPTOR

Mechanistic target of rapamycin (mTOR) complex 1 (mTORC1) integrates various environmental signals to regulate cell growth and metabolism. DEPTOR, also termed DEPDC6, is an endogenous inhibitor of mTORC1 and mTORC2 activities. The abundance of DEPTOR centrally orchestrates the mTOR signaling network...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Biol Chem
Egile Nagusiak: Zhao, Linlin, Wang, Xinbo, Yu, Yue, Deng, Lu, Chen, Lei, Peng, Xiaoping, Jiao, Chenchen, Gao, Guoli, Tan, Xiao, Pan, Weijuan, Ge, Xin, Wang, Ping
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2018
Gaiak:
Cell Biology
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5880136/
https://ncbi.nlm.nih.gov/pubmed/29382726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.809533
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