Genetic deletion of Polo-like kinase 2 reduces alpha-synuclein serine-129 phosphorylation in presynaptic terminals but not Lewy bodies

Phosphorylation of alpha-synuclein at serine-129 is an important marker of pathologically relevant, aggregated forms of the protein in several important human diseases, including Parkinson’s disease, Dementia with Lewy bodies, and Multiple system atrophy. Although several kinases have been shown to...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:J Biol Chem
Autors principals: Weston, Leah J., Stackhouse, Teresa L., Spinelli, Kateri J., Boutros, Sydney W., Rose, Elizabeth P., Osterberg, Valerie R., Luk, Kelvin C., Raber, Jacob, Weissman, Tamily A., Unni, Vivek K.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2021
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7948797/
https://ncbi.nlm.nih.gov/pubmed/33428941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100273
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars