Genetic deletion of Polo-like kinase 2 reduces alpha-synuclein serine-129 phosphorylation in presynaptic terminals but not Lewy bodies

Phosphorylation of alpha-synuclein at serine-129 is an important marker of pathologically relevant, aggregated forms of the protein in several important human diseases, including Parkinson’s disease, Dementia with Lewy bodies, and Multiple system atrophy. Although several kinases have been shown to...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:J Biol Chem
Κύριοι συγγραφείς: Weston, Leah J., Stackhouse, Teresa L., Spinelli, Kateri J., Boutros, Sydney W., Rose, Elizabeth P., Osterberg, Valerie R., Luk, Kelvin C., Raber, Jacob, Weissman, Tamily A., Unni, Vivek K.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: American Society for Biochemistry and Molecular Biology 2021
Θέματα:
Research Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7948797/
https://ncbi.nlm.nih.gov/pubmed/33428941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100273
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