Alpha-synuclein is a DNA binding protein that modulates DNA repair with implications for Lewy body disorders

Alpha-synuclein is a presynaptic protein that forms abnormal cytoplasmic aggregates in Lewy body disorders. Although nuclear alpha-synuclein localization has been described, its function in the nucleus is not well understood. We demonstrate that alpha-synuclein modulates DNA repair. First, alpha-syn...

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Publicado en:Sci Rep
Main Authors: Schaser, Allison J., Osterberg, Valerie R., Dent, Sydney E., Stackhouse, Teresa L., Wakeham, Colin M., Boutros, Sydney W., Weston, Leah J., Owen, Nichole, Weissman, Tamily A., Luna, Esteban, Raber, Jacob, Luk, Kelvin C., McCullough, Amanda K., Woltjer, Randall L., Unni, Vivek K.
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6662836/
https://ncbi.nlm.nih.gov/pubmed/31358782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-47227-z
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