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Progressive aggregation of alpha-synuclein and selective degeneration of Lewy inclusion-bearing neurons in a mouse model of parkinsonism

Aggregated alpha-synuclein inclusions are found where cell death occurs in several diseases, including Parkinson’s Disease, Dementia with Lewy Bodies and Multiple System Atrophy. However, the relationship between inclusion formation and an individual cell’s fate has been difficult to study with conv...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Osterberg, Valerie R., Spinelli, Kateri J., Weston, Leah J., Luk, Kelvin C., Woltjer, Randall L., Unni, Vivek K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4351119/
https://ncbi.nlm.nih.gov/pubmed/25732816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.01.060
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