Trans-synaptic and retrograde axonal spread of Lewy pathology following pre-formed fibril injection in an in vivo A53T alpha-synuclein mouse model of synucleinopathy

It is necessary to develop an understanding of the specific mechanisms involved in alpha-synuclein aggregation and propagation to develop disease modifying therapies for age-related synucleinopathies, including Parkinson’s disease and Dementia with Lewy Bodies. To adequately address this question, w...

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Detalhes bibliográficos
Publicado no:Acta Neuropathol Commun
Main Authors: Schaser, Allison J., Stackhouse, Teresa L., Weston, Leah J., Kerstein, Patrick C., Osterberg, Valerie R., López, Claudia S., Dickson, Dennis W., Luk, Kelvin C., Meshul, Charles K., Woltjer, Randall L., Unni, Vivek K.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7456087/
https://ncbi.nlm.nih.gov/pubmed/32859276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-020-01026-0
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