Genetic deletion of Polo-like kinase 2 reduces alpha-synuclein serine-129 phosphorylation in presynaptic terminals but not Lewy bodies

Phosphorylation of alpha-synuclein at serine-129 is an important marker of pathologically relevant, aggregated forms of the protein in several important human diseases, including Parkinson’s disease, Dementia with Lewy bodies, and Multiple system atrophy. Although several kinases have been shown to...

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Udgivet i:J Biol Chem
Main Authors: Weston, Leah J., Stackhouse, Teresa L., Spinelli, Kateri J., Boutros, Sydney W., Rose, Elizabeth P., Osterberg, Valerie R., Luk, Kelvin C., Raber, Jacob, Weissman, Tamily A., Unni, Vivek K.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2021
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7948797/
https://ncbi.nlm.nih.gov/pubmed/33428941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100273
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