Polo-like Kinase 2 (PLK2) Phosphorylates α-Synuclein at Serine 129 in Central Nervous System

Several neurological diseases, including Parkinson disease and dementia with Lewy bodies, are characterized by the accumulation of α-synuclein phosphorylated at Ser-129 (p-Ser-129). The kinase or kinases responsible for this phosphorylation have been the subject of intense investigation. Here we sub...

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Bibliografiske detaljer
Main Authors: Inglis, Kelly J., Chereau, David, Brigham, Elizabeth F., Chiou, San-San, Schöbel, Susanne, Frigon, Normand L., Yu, Mei, Caccavello, Russell J., Nelson, Seth, Motter, Ruth, Wright, Sarah, Chian, David, Santiago, Pamela, Soriano, Ferdie, Ramos, Carla, Powell, Kyle, Goldstein, Jason M., Babcock, Michael, Yednock, Ted, Bard, Frederique, Basi, Guriqbal S., Sham, Hing, Chilcote, Tamie J., McConlogue, Lisa, Griswold-Prenner, Irene, Anderson, John P.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2009
Fag:
Accelerated Publication
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2631975/
https://ncbi.nlm.nih.gov/pubmed/19004816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.C800206200
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