Elevated Alpha-Synuclein Impairs Innate Immune Cell Function and Provides a Potential Peripheral Biomarker for Parkinson's Disease

Alpha-synuclein protein is strongly implicated in the pathogenesis Parkinson's disease. Increased expression of α-synuclein due to genetic multiplication or point mutations leads to early onset disease. While α-synuclein is known to modulate membrane vesicle dynamics, it is not clear if this ac...

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Bibliographic Details
Main Authors: Gardai, Shyra J., Mao, Wenxian, Schüle, Birgitt, Babcock, Michael, Schoebel, Sue, Lorenzana, Carlos, Alexander, Jeff, Kim, Sam, Glick, Heather, Hilton, Kathryn, Fitzgerald, J. Kent, Buttini, Manuel, Chiou, San-San, McConlogue, Lisa, Anderson, John P., Schenk, Dale B., Bard, Frederique, Langston, J. William, Yednock, Ted, Johnston, Jennifer A.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3751933/
https://ncbi.nlm.nih.gov/pubmed/24058406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0071634
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