Agonist-independent Gα(z) activity negatively regulates beta-cell compensation in a diet-induced obesity model of type 2 diabetes

The inhibitory G protein alpha-subunit (Gα(z)) is an important modulator of beta-cell function. Full-body Gα(z)-null mice are protected from hyperglycemia and glucose intolerance after long-term high-fat diet (HFD) feeding. In this study, at a time point in the feeding regimen where WT mice are only...

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Dades bibliogràfiques
Publicat a:J Biol Chem
Autors principals: Schaid, Michael D., Green, Cara L., Peter, Darby C., Gallagher, Shannon J., Guthery, Erin, Carbajal, Kathryn A., Harrington, Jeffrey M., Kelly, Grant M., Reuter, Austin, Wehner, Molly L., Brill, Allison L., Neuman, Joshua C., Lamming, Dudley W., Kimple, Michelle E.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2020
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7948463/
https://ncbi.nlm.nih.gov/pubmed/33172888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.015585
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