The Inhibitory G Protein α-Subunit, Gα(z), Promotes Type 1 Diabetes-Like Pathophysiology in NOD Mice

The α-subunit of the heterotrimeric G(z) protein, Gα(z), promotes β-cell death and inhibits β-cell replication when pancreatic islets are challenged by stressors. Thus, we hypothesized that loss of Gα(z) protein would preserve functional β-cell mass in the nonobese diabetic (NOD) model, protecting f...

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Publicado en:Endocrinology
Autores principales: Fenske, Rachel J., Cadena, Mark T., Harenda, Quincy E., Wienkes, Haley N., Carbajal, Kathryn, Schaid, Michael D., Laundre, Erin, Brill, Allison L., Truchan, Nathan A., Brar, Harpreet, Wisinski, Jaclyn, Cai, Jinjin, Graham, Timothy E., Engin, Feyza, Kimple, Michelle E.
Formato: Artigo
Lenguaje:Inglês
Publicado: Endocrine Society 2017
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Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5460933/
https://ncbi.nlm.nih.gov/pubmed/28419211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2016-1700
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