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The Inhibitory G Protein α-Subunit, Gα(z), Promotes Type 1 Diabetes-Like Pathophysiology in NOD Mice
The α-subunit of the heterotrimeric G(z) protein, Gα(z), promotes β-cell death and inhibits β-cell replication when pancreatic islets are challenged by stressors. Thus, we hypothesized that loss of Gα(z) protein would preserve functional β-cell mass in the nonobese diabetic (NOD) model, protecting f...
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| Veröffentlicht in: | Endocrinology |
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| Hauptverfasser: | , , , , , , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Endocrine Society
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5460933/ https://ncbi.nlm.nih.gov/pubmed/28419211 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2016-1700 |
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