The Inhibitory G Protein α-Subunit, Gα(z), Promotes Type 1 Diabetes-Like Pathophysiology in NOD Mice

The α-subunit of the heterotrimeric G(z) protein, Gα(z), promotes β-cell death and inhibits β-cell replication when pancreatic islets are challenged by stressors. Thus, we hypothesized that loss of Gα(z) protein would preserve functional β-cell mass in the nonobese diabetic (NOD) model, protecting f...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:Endocrinology
Autors principals: Fenske, Rachel J., Cadena, Mark T., Harenda, Quincy E., Wienkes, Haley N., Carbajal, Kathryn, Schaid, Michael D., Laundre, Erin, Brill, Allison L., Truchan, Nathan A., Brar, Harpreet, Wisinski, Jaclyn, Cai, Jinjin, Graham, Timothy E., Engin, Feyza, Kimple, Michelle E.
Format: Artigo
Idioma:Inglês
Publicat: Endocrine Society 2017
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5460933/
https://ncbi.nlm.nih.gov/pubmed/28419211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2016-1700
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars