The Inhibitory G Protein α-Subunit, Gα(z), Promotes Type 1 Diabetes-Like Pathophysiology in NOD Mice

The α-subunit of the heterotrimeric G(z) protein, Gα(z), promotes β-cell death and inhibits β-cell replication when pancreatic islets are challenged by stressors. Thus, we hypothesized that loss of Gα(z) protein would preserve functional β-cell mass in the nonobese diabetic (NOD) model, protecting f...

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書誌詳細
出版年:Endocrinology
主要な著者: Fenske, Rachel J., Cadena, Mark T., Harenda, Quincy E., Wienkes, Haley N., Carbajal, Kathryn, Schaid, Michael D., Laundre, Erin, Brill, Allison L., Truchan, Nathan A., Brar, Harpreet, Wisinski, Jaclyn, Cai, Jinjin, Graham, Timothy E., Engin, Feyza, Kimple, Michelle E.
フォーマット: Artigo
言語:Inglês
出版事項: Endocrine Society 2017
主題:
Research Articles
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5460933/
https://ncbi.nlm.nih.gov/pubmed/28419211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2016-1700
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