The Inhibitory G Protein α-Subunit, Gα(z), Promotes Type 1 Diabetes-Like Pathophysiology in NOD Mice

The α-subunit of the heterotrimeric G(z) protein, Gα(z), promotes β-cell death and inhibits β-cell replication when pancreatic islets are challenged by stressors. Thus, we hypothesized that loss of Gα(z) protein would preserve functional β-cell mass in the nonobese diabetic (NOD) model, protecting f...

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Detalhes bibliográficos
Publicado no:Endocrinology
Main Authors: Fenske, Rachel J., Cadena, Mark T., Harenda, Quincy E., Wienkes, Haley N., Carbajal, Kathryn, Schaid, Michael D., Laundre, Erin, Brill, Allison L., Truchan, Nathan A., Brar, Harpreet, Wisinski, Jaclyn, Cai, Jinjin, Graham, Timothy E., Engin, Feyza, Kimple, Michelle E.
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2017
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5460933/
https://ncbi.nlm.nih.gov/pubmed/28419211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2016-1700
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