Agonist-independent Gα(z) activity negatively regulates beta-cell compensation in a diet-induced obesity model of type 2 diabetes

The inhibitory G protein alpha-subunit (Gα(z)) is an important modulator of beta-cell function. Full-body Gα(z)-null mice are protected from hyperglycemia and glucose intolerance after long-term high-fat diet (HFD) feeding. In this study, at a time point in the feeding regimen where WT mice are only...

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Pubblicato in:J Biol Chem
Autori principali: Schaid, Michael D., Green, Cara L., Peter, Darby C., Gallagher, Shannon J., Guthery, Erin, Carbajal, Kathryn A., Harrington, Jeffrey M., Kelly, Grant M., Reuter, Austin, Wehner, Molly L., Brill, Allison L., Neuman, Joshua C., Lamming, Dudley W., Kimple, Michelle E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2020
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7948463/
https://ncbi.nlm.nih.gov/pubmed/33172888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.015585
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