Agonist-independent Gα(z) activity negatively regulates beta-cell compensation in a diet-induced obesity model of type 2 diabetes

The inhibitory G protein alpha-subunit (Gα(z)) is an important modulator of beta-cell function. Full-body Gα(z)-null mice are protected from hyperglycemia and glucose intolerance after long-term high-fat diet (HFD) feeding. In this study, at a time point in the feeding regimen where WT mice are only...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Biol Chem
Egile Nagusiak: Schaid, Michael D., Green, Cara L., Peter, Darby C., Gallagher, Shannon J., Guthery, Erin, Carbajal, Kathryn A., Harrington, Jeffrey M., Kelly, Grant M., Reuter, Austin, Wehner, Molly L., Brill, Allison L., Neuman, Joshua C., Lamming, Dudley W., Kimple, Michelle E.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2020
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7948463/
https://ncbi.nlm.nih.gov/pubmed/33172888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.015585
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