Agonist-independent Gα(z) activity negatively regulates beta-cell compensation in a diet-induced obesity model of type 2 diabetes

The inhibitory G protein alpha-subunit (Gα(z)) is an important modulator of beta-cell function. Full-body Gα(z)-null mice are protected from hyperglycemia and glucose intolerance after long-term high-fat diet (HFD) feeding. In this study, at a time point in the feeding regimen where WT mice are only...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Schaid, Michael D., Green, Cara L., Peter, Darby C., Gallagher, Shannon J., Guthery, Erin, Carbajal, Kathryn A., Harrington, Jeffrey M., Kelly, Grant M., Reuter, Austin, Wehner, Molly L., Brill, Allison L., Neuman, Joshua C., Lamming, Dudley W., Kimple, Michelle E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7948463/
https://ncbi.nlm.nih.gov/pubmed/33172888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.015585
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