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DNA Damage-Induced Apoptosis and Mitogen-Activated Protein Kinase Pathway Contribute to the Toxicity of Dronedarone in Hepatic Cells

Dronedarone, an antiarrhythmic drug, has been marketed as an alternative to amiodarone. The use of dronedarone has been associated with severe liver injury; however, the mechanisms remain unclear. In this study, the possible mechanisms of dronedarone induced liver toxicity were characterized in HepG...

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Dettagli Bibliografici
Pubblicato in:Environ Mol Mutagen
Autori principali: Chen, Si, Ren, Zhen, Yu, Dianke, Ning, Baitang, Guo, Lei
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7941192/
https://ncbi.nlm.nih.gov/pubmed/29399883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/em.22173
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