Chargement en cours...

Endoplasmic reticulum stress and MAPK signaling pathway activation underlie leflunomide-induced toxicity in HepG2 Cells

Leflunomide, used for the treatment of rheumatoid arthritis, has been reported to cause severe liver problems and liver failure; however, the underlying mechanisms are not clear. In this study, we used multiple approaches including genomic analysis to investigate and characterize the possible molecu...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:Toxicology
Auteurs principaux: Ren, Zhen, Chen, Si, Qing, Tao, Xuan, Jiekun, Couch, Letha, Yu, Dianke, Ning, Baitang, Shi, Leming, Guo, Lei
Format: Artigo
Langue:Inglês
Publié: 2017
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5736314/
https://ncbi.nlm.nih.gov/pubmed/28988120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tox.2017.10.002
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!