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Mitochondrial dysfunction induced by leflunomide and its active metabolite

Leflunomide, an anti-inflammatory drug used for the treatment of rheumatoid arthritis, has been marked with a black box warning regarding an increased risk of liver injury. The active metabolite of leflunomide, A771726, which also carries a boxed warning about potential hepatotoxicity, has been mark...

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Dettagli Bibliografici
Pubblicato in:Toxicology
Autori principali: Xuan, Jiekun, Ren, Zhen, Qing, Tao, Couch, Letha, Shi, Leming, Tolleson, William H., Guo, Lei
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5909954/
https://ncbi.nlm.nih.gov/pubmed/29427785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tox.2018.02.003
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