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Mitochondrial dysfunction induced by leflunomide and its active metabolite
Leflunomide, an anti-inflammatory drug used for the treatment of rheumatoid arthritis, has been marked with a black box warning regarding an increased risk of liver injury. The active metabolite of leflunomide, A771726, which also carries a boxed warning about potential hepatotoxicity, has been mark...
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| Publicado no: | Toxicology |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5909954/ https://ncbi.nlm.nih.gov/pubmed/29427785 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tox.2018.02.003 |
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