Llwytho...
Development of HepG2-derived cells expressing cytochrome P450s for assessing metabolism-associated drug-induced liver toxicity
The generation of reactive metabolites from therapeutic agents is one of the major mechanisms of drug-induced liver injury (DILI). In order to evaluate metabolism-related toxicity and improve drug efficacy and safety, we generated a battery of HepG2-derived cell lines that express 14 cytochrome P450...
Wedi'i Gadw mewn:
| Cyhoeddwyd yn: | Chem Biol Interact |
|---|---|
| Prif Awduron: | , , , , |
| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
2015
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| Pynciau: | |
| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5727584/ https://ncbi.nlm.nih.gov/pubmed/26477383 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cbi.2015.10.009 |
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