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Development of HepG2-derived cells expressing cytochrome P450s for assessing metabolism-associated drug-induced liver toxicity

The generation of reactive metabolites from therapeutic agents is one of the major mechanisms of drug-induced liver injury (DILI). In order to evaluate metabolism-related toxicity and improve drug efficacy and safety, we generated a battery of HepG2-derived cell lines that express 14 cytochrome P450...

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Pubblicato in:Chem Biol Interact
Autori principali: Xuan, Jiekun, Chen, Si, Ning, Baitang, Tolleson, William H., Guo, Lei
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5727584/
https://ncbi.nlm.nih.gov/pubmed/26477383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cbi.2015.10.009
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