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The role of hepatic cytochrome P450s in the cytotoxicity of dronedarone

Dronedarone is used to treat patients with cardiac arrhythmias and has been reported to be associated with liver injury. Our previous mechanistic work demonstrated that DNA damage-induced apoptosis contributes to the cytotoxicity of dronedarone. In this study, we examined further the underlying mech...

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Detalhes bibliográficos
Publicado no:Arch Toxicol
Main Authors: Chen, Si, Wu, Qiangen, Ning, Baitang, Bryant, Matthew, Guo, Lei
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6348481/
https://ncbi.nlm.nih.gov/pubmed/29616291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00204-018-2196-x
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