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Endoplasmic Reticulum Stress Induction and ERK1/2 Activation Contribute to Nefazodone-Induced Toxicity in Hepatic Cells

Nefazodone, an antagonist for the 5-hydroxytryptanine receptor, has been used for the treatment of depression. Acute liver injury has been documented to be associated with the use of nefazodone; however, the mechanisms of nefazodone-induced liver toxicity are not well defined. In this report, using...

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Bibliografische gegevens
Gepubliceerd in:Toxicol Sci
Hoofdauteurs: Ren, Zhen, Chen, Si, Zhang, Jie, Doshi, Utkarsh, Li, Albert P., Guo, Lei
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2016
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5727583/
https://ncbi.nlm.nih.gov/pubmed/27613715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfw173
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