A combinatorial native MS and LC-MS/MS approach reveals high intrinsic phosphorylation of human Tau but minimal levels of other key modifications

Abnormal changes of neuronal Tau protein, such as phosphorylation and aggregation, are considered hallmarks of cognitive deficits in Alzheimer's disease. Abnormal phosphorylation is thought to precede aggregation and therefore to promote aggregation, but the nature and extent of phosphorylation...

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Foilsithe in:J Biol Chem
Main Authors: Drepper, Friedel, Biernat, Jacek, Kaniyappan, Senthilvelrajan, Meyer, Helmut E., Mandelkow, Eva Maria, Warscheid, Bettina, Mandelkow, Eckhard
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2021
Ábhair:
Protein Structure and Folding
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7939451/
https://ncbi.nlm.nih.gov/pubmed/33106314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.015882
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