A combinatorial native MS and LC-MS/MS approach reveals high intrinsic phosphorylation of human Tau but minimal levels of other key modifications

Abnormal changes of neuronal Tau protein, such as phosphorylation and aggregation, are considered hallmarks of cognitive deficits in Alzheimer's disease. Abnormal phosphorylation is thought to precede aggregation and therefore to promote aggregation, but the nature and extent of phosphorylation...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Drepper, Friedel, Biernat, Jacek, Kaniyappan, Senthilvelrajan, Meyer, Helmut E., Mandelkow, Eva Maria, Warscheid, Bettina, Mandelkow, Eckhard
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2021
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7939451/
https://ncbi.nlm.nih.gov/pubmed/33106314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.015882
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