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Lipid membrane templated misfolding and self-assembly of intrinsically disordered tau protein
The aggregation of the intrinsically disordered tau protein into highly ordered β-sheet-rich fibrils is implicated in the pathogenesis of a range of neurodegenerative disorders. The mechanism of tau fibrillogenesis remains unresolved, particularly early events that trigger the misfolding and assembl...
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| 發表在: | Sci Rep |
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| Main Authors: | , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Nature Publishing Group UK
2020
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7414892/ https://ncbi.nlm.nih.gov/pubmed/32770092 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-70208-6 |
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