TIA1 potentiates tau phase separation and promotes generation of toxic oligomeric tau

Tau protein plays an important role in the biology of stress granules and in the stress response of neurons, but the nature of these biochemical interactions is not known. Here we show that the interaction of tau with RNA and the RNA binding protein TIA1 is sufficient to drive phase separation of ta...

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Библиографические подробности
Опубликовано в: :Proc Natl Acad Sci U S A
Главные авторы: Ash, Peter E. A., Lei, Shuwen, Shattuck, Jenifer, Boudeau, Samantha, Carlomagno, Yari, Medalla, Maria, Mashimo, Bryce L., Socorro, Guillermo, Al-Mohanna, Louloua F. A., Jiang, Lulu, Öztürk, Muhammet M., Knobel, Mark, Ivanov, Pavel, Petrucelli, Leonard, Wegmann, Susanne, Kanaan, Nicholas M., Wolozin, Benjamin
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2021
Предметы:
Biological Sciences
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7936275/
https://ncbi.nlm.nih.gov/pubmed/33619090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2014188118
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