Reducing the RNA binding protein TIA1 protects against tau-mediated neurodegeneration in vivo

Emerging studies suggest a role for tau in regulating the biology of RNA binding proteins (RBPs). We now show that reducing the RBP T-cell intracellular antigen 1 (TIA1) in vivo protects against neurodegeneration and prolongs survival in transgenic P301S tau mice. Biochemical fractionation shows co-...

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書誌詳細
出版年:Nat Neurosci
主要な著者: Apicco, Daniel J., Ash, Peter E. A., Maziuk, Brandon, LeBlang, Chelsey, Medalla, Maria, Abdullatif, Ali Al, Ferragud, Antonio, Botelho, Emily, Ballance, Heather I., Dhawan, Uma, Boudeau, Samantha, Cruz, Anna Lourdes, Kashy, Daniel, Wong, Aria, Goldberg, Lisa R., Yazdani, Neema, Zhang, Cheng, Ung, Choong Y, Tripodis, Yorghos, Kanaan, Nicholas M., Ikezu, Tsuneya, Cottone, Pietro, Leszyk, John, Li, Hu, Luebke, Jennifer, Bryant, Camron D., Wolozin, Benjamin
フォーマット: Artigo
言語:Inglês
出版事項: 2017
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5745051/
https://ncbi.nlm.nih.gov/pubmed/29273772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41593-017-0022-z
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