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Lipid regulation of hERG1 channel function

The lipid regulation of mammalian ion channel function has emerged as a fundamental mechanism in the control of electrical signalling and transport specificity in various cell types. In this work, we combine molecular dynamics simulations, mutagenesis, and electrophysiology to provide mechanistic in...

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Publicat a:Nat Commun
Autors principals: Miranda, Williams E., Guo, Jiqing, Mesa-Galloso, Haydee, Corradi, Valentina, Lees-Miller, James P., Tieleman, D. Peter, Duff, Henry J., Noskov, Sergei Yu.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2021
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7930123/
https://ncbi.nlm.nih.gov/pubmed/33658490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21681-8
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