Impaired bile secretion promotes hepatobiliary injury in Sickle Cell Disease

Hepatic crisis is an emergent complication affecting sickle cell disease (SCD) patients, however, the molecular mechanism of sickle cell hepatobiliary injury remains poorly understood. Using the knock-in humanized mouse model of SCD and SCD patient blood, we sought to mechanistically characterize SC...

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Detaylı Bibliyografya
Yayımlandı:Hepatology
Asıl Yazarlar: Vats, Ravi, Liu, Silvia, Zhu, Junjie, Mukhi, Dhanunjay, Tutuncuoglu, Egemen, Cardenes, Nayra, Singh, Sucha, Brzoska, Tomasz, Kosar, Karis, Bamne, Mikhil, Jonassaint, Jude, Michael, Adeola Adebayo, Watkins, Simon C., Hillery, Cheryl, Ma, Xiaochao, Nejak-Bowen, Kari, Rojas, Mauricio, Gladwin, Mark T, Kato, Gregory J, Ramakrishnan, Sadeesh, Sundd, Prithu, Monga, Satdarshan Pal, Pradhan-Sundd, Tirthadipa
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2020
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7923682/
https://ncbi.nlm.nih.gov/pubmed/32190913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.31239
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