Impaired bile secretion promotes hepatobiliary injury in Sickle Cell Disease

Hepatic crisis is an emergent complication affecting sickle cell disease (SCD) patients, however, the molecular mechanism of sickle cell hepatobiliary injury remains poorly understood. Using the knock-in humanized mouse model of SCD and SCD patient blood, we sought to mechanistically characterize SC...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Hepatology
Hlavní autoři: Vats, Ravi, Liu, Silvia, Zhu, Junjie, Mukhi, Dhanunjay, Tutuncuoglu, Egemen, Cardenes, Nayra, Singh, Sucha, Brzoska, Tomasz, Kosar, Karis, Bamne, Mikhil, Jonassaint, Jude, Michael, Adeola Adebayo, Watkins, Simon C., Hillery, Cheryl, Ma, Xiaochao, Nejak-Bowen, Kari, Rojas, Mauricio, Gladwin, Mark T, Kato, Gregory J, Ramakrishnan, Sadeesh, Sundd, Prithu, Monga, Satdarshan Pal, Pradhan-Sundd, Tirthadipa
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7923682/
https://ncbi.nlm.nih.gov/pubmed/32190913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.31239
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky