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Impaired bile secretion promotes hepatobiliary injury in Sickle Cell Disease

Hepatic crisis is an emergent complication affecting sickle cell disease (SCD) patients, however, the molecular mechanism of sickle cell hepatobiliary injury remains poorly understood. Using the knock-in humanized mouse model of SCD and SCD patient blood, we sought to mechanistically characterize SC...

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Vydáno v:Hepatology
Hlavní autoři: Vats, Ravi, Liu, Silvia, Zhu, Junjie, Mukhi, Dhanunjay, Tutuncuoglu, Egemen, Cardenes, Nayra, Singh, Sucha, Brzoska, Tomasz, Kosar, Karis, Bamne, Mikhil, Jonassaint, Jude, Michael, Adeola Adebayo, Watkins, Simon C., Hillery, Cheryl, Ma, Xiaochao, Nejak-Bowen, Kari, Rojas, Mauricio, Gladwin, Mark T, Kato, Gregory J, Ramakrishnan, Sadeesh, Sundd, Prithu, Monga, Satdarshan Pal, Pradhan-Sundd, Tirthadipa
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7923682/
https://ncbi.nlm.nih.gov/pubmed/32190913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.31239
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