Impaired bile secretion promotes hepatobiliary injury in Sickle Cell Disease

Hepatic crisis is an emergent complication affecting sickle cell disease (SCD) patients, however, the molecular mechanism of sickle cell hepatobiliary injury remains poorly understood. Using the knock-in humanized mouse model of SCD and SCD patient blood, we sought to mechanistically characterize SC...

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Detalhes bibliográficos
Publicado no:Hepatology
Main Authors: Vats, Ravi, Liu, Silvia, Zhu, Junjie, Mukhi, Dhanunjay, Tutuncuoglu, Egemen, Cardenes, Nayra, Singh, Sucha, Brzoska, Tomasz, Kosar, Karis, Bamne, Mikhil, Jonassaint, Jude, Michael, Adeola Adebayo, Watkins, Simon C., Hillery, Cheryl, Ma, Xiaochao, Nejak-Bowen, Kari, Rojas, Mauricio, Gladwin, Mark T, Kato, Gregory J, Ramakrishnan, Sadeesh, Sundd, Prithu, Monga, Satdarshan Pal, Pradhan-Sundd, Tirthadipa
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7923682/
https://ncbi.nlm.nih.gov/pubmed/32190913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.31239
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