Lung vaso-occlusion in sickle cell disease mediated by arteriolar neutrophil-platelet microemboli

In patients with sickle cell disease (SCD), the polymerization of intraerythrocytic hemoglobin S promotes downstream vaso-occlusive events in the microvasculature. While vaso-occlusion is known to occur in the lung, often in the context of systemic vaso-occlusive crisis and the acute chest syndrome,...

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Veröffentlicht in:JCI Insight
Hauptverfasser: Bennewitz, Margaret F., Jimenez, Maritza A., Vats, Ravi, Tutuncuoglu, Egemen, Jonassaint, Jude, Kato, Gregory J., Gladwin, Mark T., Sundd, Prithu
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2017
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5214368/
https://ncbi.nlm.nih.gov/pubmed/28097236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.89761
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