Platelet Extracellular Vesicles Drive Inflammasome–IL-1β–Dependent Lung Injury in Sickle Cell Disease

Rationale: Intraerythrocytic polymerization of Hb S promotes hemolysis and vasoocclusive events in the microvasculature of patients with sickle cell disease (SCD). Although platelet–neutrophil aggregate–dependent vasoocclusion is known to occur in the lung and contribute to acute chest syndrome, the...

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Detalhes bibliográficos
Publicado no:Am J Respir Crit Care Med
Main Authors: Vats, Ravi, Brzoska, Tomasz, Bennewitz, Margaret F., Jimenez, Maritza A., Pradhan-Sundd, Tirthadipa, Tutuncuoglu, Egemen, Jonassaint, Jude, Gutierrez, Edgar, Watkins, Simon C., Shiva, Sruti, Scott, Melanie J., Morelli, Adrian E., Neal, Matthew D., Kato, Gregory J., Gladwin, Mark T., Sundd, Prithu
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2020
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6938158/
https://ncbi.nlm.nih.gov/pubmed/31498653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.201807-1370OC
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