Platelet Extracellular Vesicles Drive Inflammasome–IL-1β–Dependent Lung Injury in Sickle Cell Disease

Rationale: Intraerythrocytic polymerization of Hb S promotes hemolysis and vasoocclusive events in the microvasculature of patients with sickle cell disease (SCD). Although platelet–neutrophil aggregate–dependent vasoocclusion is known to occur in the lung and contribute to acute chest syndrome, the...

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Bibliografski detalji
Izdano u:Am J Respir Crit Care Med
Glavni autori: Vats, Ravi, Brzoska, Tomasz, Bennewitz, Margaret F., Jimenez, Maritza A., Pradhan-Sundd, Tirthadipa, Tutuncuoglu, Egemen, Jonassaint, Jude, Gutierrez, Edgar, Watkins, Simon C., Shiva, Sruti, Scott, Melanie J., Morelli, Adrian E., Neal, Matthew D., Kato, Gregory J., Gladwin, Mark T., Sundd, Prithu
Format: Artigo
Jezik:Inglês
Izdano: American Thoracic Society 2020
Teme:
Original Articles
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6938158/
https://ncbi.nlm.nih.gov/pubmed/31498653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.201807-1370OC
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