Platelet Extracellular Vesicles Drive Inflammasome–IL-1β–Dependent Lung Injury in Sickle Cell Disease

Rationale: Intraerythrocytic polymerization of Hb S promotes hemolysis and vasoocclusive events in the microvasculature of patients with sickle cell disease (SCD). Although platelet–neutrophil aggregate–dependent vasoocclusion is known to occur in the lung and contribute to acute chest syndrome, the...

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Publicado en:Am J Respir Crit Care Med
Autores principales: Vats, Ravi, Brzoska, Tomasz, Bennewitz, Margaret F., Jimenez, Maritza A., Pradhan-Sundd, Tirthadipa, Tutuncuoglu, Egemen, Jonassaint, Jude, Gutierrez, Edgar, Watkins, Simon C., Shiva, Sruti, Scott, Melanie J., Morelli, Adrian E., Neal, Matthew D., Kato, Gregory J., Gladwin, Mark T., Sundd, Prithu
Formato: Artigo
Lenguaje:Inglês
Publicado: American Thoracic Society 2020
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Original Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6938158/
https://ncbi.nlm.nih.gov/pubmed/31498653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.201807-1370OC
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