Inhibitors of cullin-RING E3 ubiquitin ligase 4 with antitumor potential

Cullin-RING (really intersting new gene) E3 ubiquitin ligases (CRLs) are the largest E3 family and direct numerous protein substrates for proteasomal degradation, thereby impacting a myriad of physiological and pathological processes including cancer. To date, there are no reported small-molecule in...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Wu, Kenneth, Huynh, Khoi Q., Lu, Iris, Moustakim, Moses, Miao, Haibin, Yu, Clinton, Haeusgen, Matthew J., Hopkins, Benjamin D., Huang, Lan, Zheng, Ning, Sanchez, Roberto, DeVita, Robert J., Pan, Zhen-Qiang
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2021
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7923628/
https://ncbi.nlm.nih.gov/pubmed/33602808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2007328118
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