Influenza hemagglutinin-specific IgA Fc-effector functionality is restricted to stalk epitopes

In this study, we utilized a panel of human immunoglobulin (Ig) IgA monoclonal antibodies isolated from the plasmablasts of eight donors after 2014/2015 influenza virus vaccination (Fluarix) to study the binding and functional specificities of this isotype. In this cohort, isolated IgA monoclonal an...

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Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Proc Natl Acad Sci U S A
Päätekijät: Freyn, Alec W., Han, Julianna, Guthmiller, Jenna J., Bailey, Mark J., Neu, Karlynn, Turner, Hannah L., Rosado, Victoria C., Chromikova, Veronika, Huang, Min, Strohmeier, Shirin, Liu, Sean T. H., Simon, Viviana, Krammer, Florian, Ward, Andrew B., Palese, Peter, Wilson, Patrick C., Nachbagauer, Raffael
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: National Academy of Sciences 2021
Aiheet:
Biological Sciences
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7923359/
https://ncbi.nlm.nih.gov/pubmed/33593910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2018102118
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