Influenza hemagglutinin-specific IgA Fc-effector functionality is restricted to stalk epitopes

In this study, we utilized a panel of human immunoglobulin (Ig) IgA monoclonal antibodies isolated from the plasmablasts of eight donors after 2014/2015 influenza virus vaccination (Fluarix) to study the binding and functional specificities of this isotype. In this cohort, isolated IgA monoclonal an...

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Publicado en:Proc Natl Acad Sci U S A
Autores principales: Freyn, Alec W., Han, Julianna, Guthmiller, Jenna J., Bailey, Mark J., Neu, Karlynn, Turner, Hannah L., Rosado, Victoria C., Chromikova, Veronika, Huang, Min, Strohmeier, Shirin, Liu, Sean T. H., Simon, Viviana, Krammer, Florian, Ward, Andrew B., Palese, Peter, Wilson, Patrick C., Nachbagauer, Raffael
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2021
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7923359/
https://ncbi.nlm.nih.gov/pubmed/33593910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2018102118
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